For patients assessed to be at a high risk for contracting colorectal cancer, this chart outlines appropriate screening and follow-up sequences.
|Condition||Genes (Inheritance) || Key Clinical Features |
|Polyposis syndrome|| |
|Familial adenomatous polyposis |
|APC (AD)||100s–1,000s of colonic adenomatous polyps |
Onset in teenage years
Prophylactic proctocolectomy is standard
|Attenuated FAP ||PC (AD)||<100 colonic adenomas, onset in adulthood|
|MYH-associated polyposis ||MUTYH (AR)||Wide range in number of colon adenomas (few–1,000s)|
|Polymerase proofreading-associated polyposis ||POLD1, POLE (AD)||5–100 colon adenomas; Increased risk of endometrial cancer|
|Peutz-Jeghers Syndrome||STK11 (AD)||Peutz-Jeghers type hamartomatous polyps |
Perioral macular pigmentation
High risk of colon, gastric, pancreatic, breast, and gynecologic cancers
|Cowden Syndrome ||PTEN (AD)||Multiple hamartomatous polyps |
High risk of thyroid cancer, breast cancer
|Bannayan-Riley-Ruvalcaba ||PTEN (AD)||Multiple hamartomatous polyps |
|Juvenile polyposis ||BMPR1A, SMAD4 (AD)||Multiple juvenile polyps |
Increased risk of colon cancer
Hereditary hemorrhagic telangiectasia phenotype in some SMAD4 families
|Serrated polyposis ||Unknown||Multiple sessile serrated adenomas (at least five serrated polyps proximal to sigmoid colon, |
two of which are >1cm in size)
|Nonpolyposis syndrome|| |
|Lynch ||MLH1, MSH2, MSH6, PMS2, EPCAM (AD)||High risk of colon and endometrial cancer |
Absence of multiple polyps
Most common hereditary colon cancer syndrome
|AD autosomal dominant |
AR autosomal recessive
More CRICO Guidelines or Algorithms
CRICO decision support tools.
General Informed Consent Guidelines
A document to assist institutions in reviewing policies, procedures and forms relative to obtaining and documenting informed consent.
Challenge: Take the OB Clinical Guidelines Test
Take this test and see if you already follow these best practices from the Obstetrical Services of the CRICO-insured Institutions.
OB Guideline 15: Assessment and Monitoring in Labor and Delivery
During prenatal care, the clinician and patient will discuss common events and procedures in labor, including methods of assessing fetal well-being.
Obstetrics Guidelines Listing
Easily navigate this web-based version of the OB guidelines 1-35 and the sample form appendices A-H. The OB Guidelines PDF is also available on this page if you want to read or print it in booklet form. (2022 version available)