Presenting Symptoms Independently Predict Mortality in Septic Shock: Importance of a Previously Unmeasured Confounder

  • June 29, 2018

This CRICO-funded study tested the hypothesis that “vague presenting symptoms are associated with delayed antibiotics and increased mortality.” 

Study Conclusion: More  than  one  third  of  patients  with  septic  shock  presented  to  the  emergency  department  with  vague  symptoms  that  were  not  specific  to  infection.  These  patients  had  delayed  antibiotic  administration  and  higher  risk  of  mortality  even  after  controlling  for  demographics,  illness  acuity,  and  time-to-antibiotics in multivariate analysis. These findings suggest that the nature of presenting symptoms is an important component of sepsis clinical phenotyping and may be an important confounder in sepsis epidemiologic studies.


Citation for the Full-text Article

Filbin MR. Lynch J, Gillingham TD, Thorsen JE, Pasakarnis CL, Nepal S, Matsushima M, Rhee C, Heldt T, Reisner AT. Presenting symptoms independently predict mortality in septic shock: Importance of a previously unmeasured confounder. Critical Care Medicine. June 29, 2018. Published Online Ahead of Print.